The complexities of the ubiquitin system are fully described in Nature 2009 vol 458 pages 422 to 467. Page 422 Hochstrasser Origin and function of ubiquitin-like proteins. The function of proteins can be modulated through a wide array of post-translational modifications. One such modification in eukaryotic cells is ubiquitylation – the covalent attachment of a…
Read moreThis paper by Brett and colleagues is such a good study of flavone metabolism. Oranges are rich sources of flavonoids that are bioactive and may protect against age-related diseases. The absorption of orange flavanones may be affected by factors such as processing and subject anthropometric variables, and the bioactivity of the absorbed phytochemicals depends on…
Read moreBurdge and colleagues discuss the substantial evidence which shows that constraints in the early life environment are an important determinant of risk of metabolic disease in adult life.. There is emerging evidence that higher birth weight, which reflects a more abundant prenatal environment, is associated with increased cancer, in particular breast cancer and childhood leukaemia.…
Read moreInflammation and endothelial activation are associated with an increased risk of vascular disease. Epidemiological evidence suggests an association between levels of markers of inflammation or endothelial activation and the intake of fruit. Vitamin E, a fat-soluble antioxidant, has anti-inflammatory properties. Dalgard and colleagues performed a randomised 2 X 2 factorial, crossover trial to determine the…
Read moreA single bout of prolonged, moderate-intensity endurance exercise lowers fasting and postprandial triacylglycerolaemia concentrations the next day. However, the triacylglycerolaemia -lowering effect of exercise is dose-dependent and does not manifest after light exercise of low energy input.. Maraki and colleagues have described a study examining if adding mild energy intake restriction to such exercise, in…
Read moreThis is complex thinking but indicates how easy it is to be rite about global warming and to think the answers are easy. The absorption of carbon by oceans is an important feature of the carbon chain and this is an important article by Gruber in Nature 11th March 2009Recent studies have suggested that the…
Read moreThis is complex thinking but indicates how easy it is to be rite about global warming and to think the answers are easy. The absorption of carbon by oceans is an important feature of the carbon chain and this is an important article by Gruber in Nature 11th March 2009Recent studies have suggested that the…
Read moreA commentary in nature 12th March 2009 discusses ways of combating the starvation or sub clinical malnutrition, which wrecks nearly 1000 million people in the world. Instead of food aid that farming be encouraged or that food be bought locally and given. This is recommendation of the Food and Agriculture Organization of the United Nations.The…
Read moreThe BMJ of 14th March2009 has two articles on the avoidance of stokes.The first by Myint et al show that four health variables smoking, physical activity, alcohol intake and frit and vegetable intake ( measured by vitamin C serum concentration ) produce a substantial reduction in risk of a stroke.Smoking is shown is great detail…
Read moreThis does not appear to be of any relevance to nutrition. I think this kind of discovery is central to the future of our science. Nutrition may play a central role in these process of control. Maybe by the usual chemicals in amino acids, proteins carbohydrates and lipids or less directly with plant secondary metbaolitres.The…
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