Monthly Archives: July 2007

AKT1, mutation and cancer aetiology

John D. Carpten et al A transforming mutation in the pleckstrin homology domain of AKTl in cancerNature 2007, vol 448, 439-444It is important for Nutritionists to appreciate the profound discoveries which are being made in Molecular Biology . There are so many naïve statements associating all manner of dietary excesses or deficiencies and cancer aetiology,…

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obesity and inflammatory proceses.

In the May 21st 2007, Nature vol 447, pp 525-7 Kendall Powell gives a chatty account of fat metabolismIt is worth readingOne thing that did occur to me was a result of the reminder that adipose tissue produces TNFά, and cytokine interleukin both indicators of low grade inflammatory processes. In addition macrophages invade fat tissue,…

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aetiology of childhood obesity

Childhood and adult obesity is a real problem. There are so many bottoms around which require two seats to fit their shape.There is a brilliant review on the aetiology of childhood obesity in the Nutrition Research Review, 2007, 20, 29-45 by KL Procter..Of the models suggested to account for this increase the one chosen is…

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A interesting coincidence , diet induced longevity and gastric cancer

In a blog published earlier today I wrote about PHA-4 and SKN-1 which extend survival after dietary restriction in these roundworms. These two proteins are transcription factors, which regulate the expression of many genes. They may also trigger hormones that coordinate physiological responses to dietary restriction.The PHA-4 protein, was originally described for its role in…

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prions, structure, infectivity and amyloid formation.

There is a commentary and paper in the Nature of 31st of May 2007 on prion of great interest..Prions are proteins which form insoluble amyloid structures associated with neurodegenerative disorders in mammals. The intriguing place of prions is that they are proteins whose conformation and ability for amyloid formation is self-seeding) and thereby infectious. The…

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diet and longevity

Dietary restriction, which means a reduction of food intake by 40-60% without causing malnutrition can benefit health and extend lifespan of yeast, worms, flies, rodents and perhaps even primates. In the May 31st copy of Nature two papers important insights are given for the mechanism.After dietary restriction, the small roundworm Caenorhabditis elegans. livses 20-50% longer…

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