John D. Carpten et al A transforming mutation in the pleckstrin homology domain of AKTl in cancerNature 2007, vol 448, 439-444It is important for Nutritionists to appreciate the profound discoveries which are being made in Molecular Biology . There are so many naïve statements associating all manner of dietary excesses or deficiencies and cancer aetiology,…
Read moreIn the May 21st 2007, Nature vol 447, pp 525-7 Kendall Powell gives a chatty account of fat metabolismIt is worth readingOne thing that did occur to me was a result of the reminder that adipose tissue produces TNFά, and cytokine interleukin both indicators of low grade inflammatory processes. In addition macrophages invade fat tissue,…
Read moreIn an article in New Engl J of Med 2007, 357, 135-42 it was an articleNeural tube defects and fortification of flour with folic acid.In 1998 the Canadian Government decreed that cereal products should be fortified with folic acid.Following which there has been a 46% reduction in all neural tube defects , spina bifida reduced…
Read moreChildhood and adult obesity is a real problem. There are so many bottoms around which require two seats to fit their shape.There is a brilliant review on the aetiology of childhood obesity in the Nutrition Research Review, 2007, 20, 29-45 by KL Procter..Of the models suggested to account for this increase the one chosen is…
Read moreJames P. Hogan et al review The physiological and metabolic impacts on sheep and cattle of feed and water deprivation before and during transport in Nutrition Research Reviews (2007). 20. 17-28In traditional livestock farming systems, animals were driven across land on foot, receiving food and water en route, but nowadays they are nearly always transported…
Read moreIn Nutrition Research Review 2007 , 20, 89-105, T. P. Dew.et al write on Bone mineral density, polyphenols and caffeine: a reassessmentIn an ageing society, the maintenance of good bone health with age is important. In osteoporosis, bone becomes increasingly porous, resulting in both greater chance and severity of bone fracture at the hip. spine,…
Read moreIt is useful to have a algorithm which enables a prediction of whether an individual is a t risk of coronary heart disease. The middle aged rotund plethoric faced cigarette smoking bloke is a cert for a coronary. But what about the others.Hippisley-Cox and her colleagues in BMJ , 2007 Derivation: prospective open cohort study…
Read moreIn a blog published earlier today I wrote about PHA-4 and SKN-1 which extend survival after dietary restriction in these roundworms. These two proteins are transcription factors, which regulate the expression of many genes. They may also trigger hormones that coordinate physiological responses to dietary restriction.The PHA-4 protein, was originally described for its role in…
Read moreThere is a commentary and paper in the Nature of 31st of May 2007 on prion of great interest..Prions are proteins which form insoluble amyloid structures associated with neurodegenerative disorders in mammals. The intriguing place of prions is that they are proteins whose conformation and ability for amyloid formation is self-seeding) and thereby infectious. The…
Read moreDietary restriction, which means a reduction of food intake by 40-60% without causing malnutrition can benefit health and extend lifespan of yeast, worms, flies, rodents and perhaps even primates. In the May 31st copy of Nature two papers important insights are given for the mechanism.After dietary restriction, the small roundworm Caenorhabditis elegans. livses 20-50% longer…
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