obesity and low grade inflammation

Hotamisligil has reviewed obesity and its related low grade inflammatory changes. Obesity is associated with chronic low-grade inflammation. Inflammatory signals interfere with insulin action and disrupt metabolic homeostasis. The c-Jun N-terminal kinase (JNK) has been identified as a central mediator of insulin resistance. Recent studies showed that in obesity compromising endoplasmic reticulum (ER) function results…

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obesity and inflammatory proceses.

In the May 21st 2007, Nature vol 447, pp 525-7 Kendall Powell gives a chatty account of fat metabolismIt is worth readingOne thing that did occur to me was a result of the reminder that adipose tissue produces TNFά, and cytokine interleukin both indicators of low grade inflammatory processes. In addition macrophages invade fat tissue,…

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