prions and Alzheimers disease

Alzheimer’s disease yield is associated with an abnormal build-up of amyloid-β (Aβ) peptides( 40-42 amino acids length) in the brain. Small, soluble aggregates of A β-A β oligomers – impair memory by disrupting memory-related functions of synaptic junctions between neurons. Lauren et al in Nature show that the prion protein might mediate the pathogenic effects…

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prions, structure, infectivity and amyloid formation.

There is a commentary and paper in the Nature of 31st of May 2007 on prion of great interest..Prions are proteins which form insoluble amyloid structures associated with neurodegenerative disorders in mammals. The intriguing place of prions is that they are proteins whose conformation and ability for amyloid formation is self-seeding) and thereby infectious. The…

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