One-carbon metabolites choline and homocysteine.are important for brain function. The relationship between the one-carbon metabolites choline. betaine. methionine and dimethylglycinc with cognition in elderly has been looked at by Simone et al in a population of elderly Dutch people as a double-blind, placebo-controlled trial.Individuals (n 195) were randomized to receive daily oral capsules with either…
Read moreSupplements to lower homocysteine concentration disappoint againEpidemiological and genetic studies show a clear association between high serum concentrations of homocysteine and a higher risk of cardiovascular disease. So for more than a decade, researchers have been trying to reduce the risk of cardiovascular disease by giving people homocysteine lowering supplements of B vitamins and folic…
Read moreThe role of raised total plasma homocysteine concentrations and cardiovascular disease is not proving to be as clear cut as originally hoped. Whilst raised total plasma homocysteine concentrations are associated with cardiovascular disease in observational studies, clinical trials have not realised these expectations, raising the possibility that raised total plasma homocysteine concentrations are innocent bystanders.Several…
Read moreFolic acid, homocysteine and cardiovascular diseaseBMJ 2006, 333, 114-7 Wald and his colleagues have published a meta analysis of Folic acid, homocysteine and cardiovascular disease, judging causality in the face of inconclusive trial evidence.Meta ananysis of cohort studies show significant positive associations betwen serum homocysteine concentrations and ischaemic heart events and stroke. A 3 umol…
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