This important review discusses this key subject of p53 and cancer aetiology. Whibley et al l2009 p53 polymorphisms: cancer implications Nature Reviews Cancer vol 9, 95-107 The normal functioning of p53 is a potent barrier to cancer. Tumour-associated mutations in TP53, typically single nucleotide substitutions in the coding sequence, are a hallmark of most human…
Read moreThis is such an intriguing paper. Many lay people believe that there is a relationship between stress and the development of cancer. The tumour suppressor p53 is activated following stress and initiates a heterogeneous response in a cell-, tissue- and stress-dependent manner. This heterogeneity is reflected in the different physiological outcomes that follow p53 activation.…
Read moreP53 is regarded as the guardian of the genome, which regulates the cellular response to stress. It is a tumour suppressor gene , but does p53 have a physiological role? It has a function in maternal reproduction. Sufficient LIF ( leukaemia inhibitory factor) a cytokine is required for implantation of the fertilised ovum and the…
Read moreIt is always satisfying when the hints developed by epidemiology ae shown in experiments to be true.Some epidemiological observations ( e.g. smoking and cancer of the lung and jumping from the 22nd floor of a building is fatal) stand in their own right.Others point the directionOne such indicator is that starvation reduces the chances of…
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