p53 and cancer.

This important review discusses this key subject of p53 and cancer aetiology. Whibley et al l2009 p53 polymorphisms: cancer implications Nature Reviews Cancer vol 9, 95-107 The normal functioning of p53 is a potent barrier to cancer. Tumour-associated mutations in TP53, typically single nucleotide substitutions in the coding sequence, are a hallmark of most human…

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carcinogenesis, p53 and stress

This is such an intriguing paper. Many lay people believe that there is a relationship between stress and the development of cancer. The tumour suppressor p53 is activated following stress and initiates a heterogeneous response in a cell-, tissue- and stress-dependent manner. This heterogeneity is reflected in the different physiological outcomes that follow p53 activation.…

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Physiological p53 function

P53 is regarded as the guardian of the genome, which regulates the cellular response to stress. It is a tumour suppressor gene , but does p53 have a physiological role? It has a function in maternal reproduction. Sufficient LIF ( leukaemia inhibitory factor) a cytokine is required for implantation of the fertilised ovum and the…

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