autophagy and starvation

AutophagyAutophagy occurs when cells need to degrade their constituents. This occurs in most normal cells to prevent the accumulation of protein aggregates and defective cellular substructures. During starvation, high temperature, low oxygen, hormonal stimulation or intracellular stress (damaged organelles, accumulation of mutant proteins, microbial invasion) there is activation of signalling pathways that increase autophagy.The enzyme…

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Human Survival without food

The ability of individuals to survive without food is well demonstrated by the awful experiences in Concentration Camps and more recently by the Irish Hunger strikers. Women appear to last longer than men and over all the body mass at the outset is a predictor of length of survival. The amount of water available is…

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