p53 and cancer.
This important review discusses this key subject of p53 and cancer aetiology. Whibley et al l2009 p53 polymorphisms: cancer implications Nature Reviews Cancer vol 9, 95-107 The normal functioning of p53 is a potent barrier to cancer. Tumour-associated mutations in TP53, typically single nucleotide substitutions in the coding sequence, are a hallmark of most human…
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