This is an interesting Review of the Metabolic syndrome: from epidemiology to systems biology
The Metabolic syndrome is a group of metabolic conditions that occur together and promote the development of cardiovascular disease and diabetes. Recent genome-wide association studies have identified several novel susceptibility genes for Metabolic syndrome traits, and studies in rodent models have provided important molecular insights. However, as yet, only a small fraction of the genetic component is known. Systems-based approaches that integrate genomic, molecular and physiological data are complementing traditional genetic and biochemical approaches to more fully address the complexity of Metabolic syndrome.
Lusis, Attie & Reue 2008 Metabolic syndrome: from epidemiology to systems biology Nature Reviews Genetics 9, 819-830 (November 2008) |

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Martin Eastwood

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