Effects of various food ingredients on gall bladder emptying The emptying of the gall bladder in response to feeding is important for the digestion of fat, but the role of various food ingredients in contracting the gall bladder postprandially is not well understood. This study looked at how different food ingredients, when consumed, will have…
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A prominent role for the brain in glucose homeostasis was proposed by scientists in the nineteenth century. Throughout most of the twentieth century research focused on evidence that the function of pancreatic islets is both necessary and sufficient to explain glucose homeostasis, and that diabetes results from defects of insulin secretion, action or both. However,…
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Adipose triglyceride lipase (ATGL) is rate limiting in the mobilization of fatty acids from cellular triglyceride stores. Adipose triglyceride lipase is a recently described adipose-enriched protein with triglyceride-specific lipase activity This central role in lipolysis marks ATGL as an interesting pharmacological target as deregulated fatty acid metabolism is closely linked to dyslipidemic and metabolic disorders.…
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William Sutherland writing in Nature 14th November vol 503 p 167 talks of Review by quality not quantity for better policy. Society increasingly demands that policies are based on scientific evidence. Yet he claims Policy makers rarely refer to the journal papers- basing their missives on summaries, reviews and assessments. Such assessments can be deeply…
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Parental eating behaviour traits have been shown to be related to the adiposity of their young children. It is not known if this relationship persists in older offspring or whether rigid or flexible control are involved. The objective of this study was to test the hypothesis that parental eating behavior traits, as measured by the…
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Briggs et al Overall and income specific effect on prevalence of overweight and obesity 0f 20% sugar sweetened drink tax in UK: econometric and comparative risk assessment. 2013 BMJ vol 347 pp 14 Leader on this topic Block BMJ vol 347 p 7 In the United States 12-19 year olds ingest 300 cals a day…
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Gastric cancer Age standardised mortality rates for this malignancy are 14.3 / 100,0000for men and 6.9 for women. Incidence is very geographically varied, highest in Eastern Asia, Eastern Europe and South America and lowest in parts of Africa. Half the patients have incurable cancer at presentation. The risk factors for gastric cancer are Helicobacter pylori…
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A well-honed adage in nutrition is the recommendation to eat five pieces of fruit and vegetables a day. Which is a worthy and reasonable suggestion. But. Where is the evidence based on epidemiology that this is based on facts. More importantly where will these five fruit and vegetables come from. In the UK there are…
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David Barker, who died recently made an important observation . He challenged the idea that diabetes, cardiovascular disease and cancer were the result of poor genes and unhealthy adult life style. He proposed that their origin lay in early life, from the nourishment a baby in the womb and its exposure to infection after birth.…
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Crispr technique and DNA Congenital abnormalities place a heavy burden on individuals and the health care system For the first time, scientists are able to engineer any part of the human genome with extreme precision using a revolutionary new technique called Crispr which has been likened to editing the individual letters on any chosen page…
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