Huntington’s disease and ubiquitin

Huntington’s disease or Huntington’s chorea is a terrible dominantly inherited neurodegenerative disease. The basis of this problem is an accumulation of fragments of polyglutamine expanded protein in affected neurons. There is also in Huntington’s disease and Alzheimers an abnormal enrichment of ubiquitin . . Ubiquitin metabolism may be in disarray. Ubiquitin is widely found in…

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