Cholesterol synthesis control

Cholesterol synthesis is controlled significantly by the hepatic HMG Co A reductase. Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase produces mevalonate, an important intermediate in the synthesis of cholesterol and essential nonsterol isoprenoids. The reductase is subject to a range of forms of feedback control through various mechanisms mediated by sterol and nonsterol end-products of mevalonate…

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