Adaptive reduction in thermogenesis and resistance to lose fat in obese men
Adaptive thermogenesis is defined as a greater than predicted change in energy expenditure in response to changes in energy balance. This issue is particularly relevant in the context of a weight-reducing programme in which diminished thermogenesis can be sufficient to compensate for a prescribed decrease in daily energy intake.
In the pilot study,described in this paper Tremblay and Chaput in British Journal of Nutrition investigated the adaptive reduction in thermogenesis in resting state that appears to favour resistance to further weight loss.
Eight obese men (mean BMI: 33•4kglm2, mean age: 38 years) participated in this repeated-measures, within-subject, clinical intervention. They were subjected to a weight-loss programme that consisted of a supervised diet (- 2930 kJ/d) and exercise clinical intervention.
The phases investigated were as follows: (i) baseline, (ii) after 5 (SE I) kg loss of body weight (phase 1), (iii) after 10 (SE 1) kg weight loss (phase 2) and (iv) at resistance to further weight loss (plateau).
At each phase of the weight-reducing programme, body weight and composition as well as Resting Metabolic Rate were measured. A regression equation was established in a control population of the same age to predict Resting Metabolic Rate obese men at each phase of the weight-loss programme. They observed that body weight and Fat Mass were significantly reduced (PIn phase 1, measured Resting Metabolic Rate had fallen by 418kJ/d, more than predicted (PTremblay and Chaput suggest that these results show that adaptive reduction in thermogenesis may contribute to the occurrence of resistance to lose fat in obese men subjected to a weight-reducing programme.

Tremblay and Chaput 2009 Adaptive reduction in thermogenesis and resistance to lose fat in obese men Brit J Nutrition vol 101 488-492

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