Ma and colleagues looked at studies of the effects of isoflavone intake on bone resorption and bone formation with a meta-analysis, of randomized controlled trials using urinary deoxypyridinoline, a bone resorption marker) and serum bone-specific alkaline phosphatase, a bone formation marker)
Nine studies with a total of 432 subjects were selected for meta-analysis. The urinary deoxypyridinoline concentration in subjects who consumed isoflavones decreased significantly. in comparison with that in subjects who did not consume isoflavones.
They concluded that soy soflavone intervention significantly inhibits bone resorption and stimulates bone formation in menopausal women:. These favorable effects occur even if less than 90mg/day of isoflavones are consumed or the intervention lasts less than 12 weeks.
Ma et al ( 2008)Soy isoflavone intake inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials. European Journal of Clinical Nutrition 62, 155–161;

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