methylation and all that

Methylation and all thatMammals use methylation for the heritable silencing of retrotransposons and imprinted genes and for the inactivation of the X chromosome in females.The establishment of patterns of DNA methylation during gametogenesis depends upon DNMT3L, an enzymatically inactive regulatory factor that is related in sequence to the DNA methyltransferase DNMT3A and DNMT3B. DNMT3L interacts…

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