genes and cancer of the colon

Genes and the aetiology of colonic cancer.Sansom O J et al 2007, Nature April 5th , vol 446, 676-679The APC gene encodes the adenomatous polyposis coli tumour suppressor protein. Mutation of the germline characterizes familial adenomatous polyposis (FAP), an autosomal intestinal cancer syndrome. Inactivation of APC is also recognized as the key early event in…

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RNA control of genes

RNA interference, or RNAi. When a gene is to be expressed, it sends instructions to the cell’s protein synthesis machinery. The intermediary is messenger RNA (mRNA), which has a structure complementary to that of the gene. In their paper, published in Nature in 1998, Fire and Mello, and colleagues, demonstrated that these mRNAs can be…

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