BRA I and breast cancer

This is an important paper indicating the molecular biology of cancer of the breast. The amino (N) terminus of BRCA 1 has a RING domain that interacts with ubiquitin-conjugating enzymes and is required for its ubiquitin ligase activity. Ligase enzymes catalyse the joining together ofmolecules of two substances and with a breaking of a diphopsatebond…

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