cancer and ALK tyrosine kinase

Lung cancer is the major and most preventable cause of cancer world wide. 80% of these tumours are non-small cell lung cancers. An article and a summarising article in Nature
Meyerson M Broken genes in solid tumours Nature 2007, 448, 545-6
Soda M Identification of the transforming EML4-ALK fusion gene in non small cell lung cancer. Nature 2007, 448,561-566
Shows that a position change of a gene associated with this form of cancer on chromosome 2 activates the gene ALK which encodes ALK tyrosine kinase. Tyrosine kinase regulate the activity of other proteins by adding phosphate to their tyrosine groups. The inhibition of such a gene expression has great potential in cancer therapy. And for a nutritionist these findings indicate that these transfer reactions may be amenable to some dietary change . Who know?.

Martin Eastwood
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