Accurate measurements are critical to any scientific exercise. Bone mineral density monitoring is by dual energy x ray absorptiometry which is costly . A well recognised method. Bisphonate treatment( alendronate ) reduces the risk of fractures ,but does not relief pain from existing fractures and may have side effects. A side product of a trail of the effectiveness of bisphonate treatment was an evaluation of dual energy x ray absorptiometry and its ability to show significant change in bone mineral density and predict if any changes in bone mineral density were valuable in predicting fractures.
The results for an individual over time were so variable and the results did not allow prediction of fracture risk.
Another variable is that compliance with treatment is not god.
Bell et al 2009 Value of routine monitoring of bone mineral density after starting bisphonate treatment : secondary analysis of trail data. BMJ vol 338 1553
Compston 2009 Monitoring bone mineral density during antiresorptive treatment for osteoporosisisBMJ vol 338 1511-1513
- Martin Eastwood