This is an interesting Perspective on turning anti-ageing genes against cancer. In such fluid states nutrition is bound to have a role.
Recent studies in diverse organisms implicate proto-oncogenic pathways, including insulin-like growth factor-I (IGF-I), Ras and AKT/protein kinase B in the ageing process. Although IGF-I is thought to contribute to cancer by promoting growth and preventing apoptosis, evidence from model organisms suggests that proto-oncogene homologues might contribute to the DNA mutations and chromosomal damage that are observed in tumour cells by increasing DNA damage, in both dividing and non-dividing cells, and involving error-prone systems in DNA repair. This raises the possibility that cancer can be reduced by chronic down regulation of pro-ageing pathways.
Longo, Lieber & Vijg ( 2008 ) Perspective on turning anti-ageing genes against cancer. Nature Reviews Molecular Cell Biology 9, 903-910 (November 2008)
- Martin Eastwood