Sirtuins are members of a class of enzyme, deacetylases which remove acetyl groups from proteins. Sirtuin activators increase yeast life span by 70%.
It is possible but not absolute that a compound resveratrol may activate sirtuins. A possible mechanism for the putative activity of resveratrol is similar to caloric restriction.
It is rumoured that resveratrol is the component of red wine that has health benefits.
Ledford 2010 Much ado about ageing Nature 464 pp 481-2

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