The combination of physical fitness as well as diet cannot be over emphasised. Much of the focus on the mechanisms of benefit of exercise and fitness have focused on prevention of atherosclerosis and its complications, the specific effects of exercise on cardiac structure and function suggest that low fitness might be particularly important for long-term…
Read moreNew research shows that a recently discovered mechanism that removes waste products from the brain is mainly active during sleep. A team, from University of Rochester Medical Center (URMC), write about their findings in Science. Lead author Dr. Maiken Nedergaard, co-director of URMC’s Center for Translational Neuromedicine, says: “This study shows that the brain has…
Read moreNutrition and rate of eating Nutrition,rate of eating Collagen stiffening The rate of absorption of dietary nutrients is important in ensuring that their post prandial blood concentration doesn’t overwhelm their metabolic processing. If this happens there is stress to the orderly metabolic system and alternative pathways used e. g. into storage tissues such as fat. …
Read moreThe relationship between tuberculosis and protein energy malnutrition M L H Hood Abstract Protein energy malnutrition and tuberculosis are the major public health issues, particularly in the developing country setting. Malnutrition is an underlying cause of many deaths and when left untreated devastates normal physical and cognitive development. TB continues to gather momentum as a…
Read moreBirth weight Birth weight, rapid weight gain in infancy and markers of overweight and obesity in childhood M R Sacco1, N P de Castro1, V L V Euclydes1, J M Souza2 and P H C Rondó1 European Journal of Clinical Nutrition (2013) 67, 1147–1153; To evaluate the relationship between birth weight and rapid weight gain…
Read moreIt is a self evidence that where ever a phenomenon in biology, there is always a claim that nutrition has a place in the process. Maybe. This might be true.Cancer is an omnipresent candidate for nutritional cause and cure. This paper is a wake up call that there are other more scientifically based possible causes…
Read moreFew safe and effective drug treatments are available. A combination treatment with sustained-release naltrexone and bupropion has been developed to produce complementary actions in CNS pathways regulating bodyweight. Two key systems are identified, the hypothalamic melanocortin sytem which integrates input related to energy balance and produces anorexigenic signalling and mesolimbic reward system which modulates reward…
Read moreMost scientists believe the function of the bone is limited to support and mineral exchange. A stimulating article in Nature discusses the possibility that bone remodelling be linked to metabolism. This makes real sense as metabolism is interconnected and a stand alone system cannot be efficient.The article discusses the work generated by Karsenty and Ducy…
Read moreThe tumour suppressor gene p53 is important in halting the cycle and death when there is DNA damage. P53 also has a role in cellular metabolism. The inactivation of p53 is common in tumours . P53 contributes to a shift from oxidative phosphorylation to glycolysis. This shift originally described by Warburg is a feature of…
Read moreSome people are naturally more anxious than others. How anxiously we react to threat or adversity is part of our personality. This characteristic is called trait anxiety, and those with high trait anxiety are more prone to mental disorders such as depression, substance abuse and psychosis. Trait anxiety is heritable, with genes explaining much of…
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