ulcerative colitis and linoleic acid

Wood 2009 IBD: High dietary intake of linoleic acid more than doubles the risk of ulcerative colitis,Nature Reviews Gastroenterology and Hepatology 7, 65
A high dietary intake of linoleic acid—an essential n-6 polyunsaturated fatty acid found in red meats, polyunsaturated margarines and various cooking oils—more than doubles the risk of developing incident ulcerative colitis, according to the results of a new multicenter European study.Linoleic acid is converted to arachidonic acid, which is incorporated into the colonocyte cell membrane; once released from the cell membrane, arachidonic acid is metabolized to proinflammatory eicosanoids (including prostaglandin E2, leukotriene B4 and thromboxane A2).

Martin Eastwood
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