P53 is regarded as the guardian of the genome, which regulates the cellular response to stress. It is a tumour suppressor gene , but does p53 have a physiological role? It has a function in maternal reproduction. Sufficient LIF ( leukaemia inhibitory factor) a cytokine is required for implantation of the fertilised ovum and the embarkation on a successful pregnancy. This is regulated by p53.
What the role in the male is remains to be seen? Also from LIF’s name there are other functions attributable to LIF which must be the start of an interesting story.
Hu et al 2007, p53 regulates maternal reproduction through LIF. Nature vol 450 pp721-724
- Martin Eastwood