p53 and metabolism

The tumour suppressor gene p53 is important in halting the cycle and death when there is DNA damage.
P53 also has a role in cellular metabolism. The inactivation of p53 is common in tumours . P53 contributes to a shift from oxidative phosphorylation to glycolysis. This shift originally described by Warburg is a feature of tumour cells.
GLS2 an enzyme involved in oxidative phosphorylation is regulated by p53 under stressed and non stressed conditions. GLS2 increases the respiration rate in mitochondria with resultant increased production of ATP.
Meline 2010 Journal Club . Nature vol 466 p 905

Martin Eastwood
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