obesity and biology of insulin resistance

This is a review of the variable effect obesity has on insulin and skeletal muscle glucose transport.
Acquired resistance to the action of insulin to stimulate glucose transport in skeletal muscle is associated with obesity and promotes the development of type 2 diabetes. In skeletal muscle, insulin resistance can result from high levels of circulating fatty acids that disrupt insulin signalling pathways. However, the severity of insulin resistance varies greatly among obese people. The authors suggest that this variability might reflect differences in levels of lipid-droplet proteins that promote the sequestration of fatty acids within adipocytes in the form of triglycerides, thereby lowering exposure of skeletal muscle to the inhibitory effects of fatty acids.
Adilson Guilherme et al (2008 )Adipocyte Adipocyte dysfunctions linking obesity to insulin resistance and type 2 Nature Reviews Molecular Cell Biology 9, 367-377

Martin Eastwood
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