histones and cancer

Post-translational modification of histones provides an important regulatory platform for processes such as gene transcription and DNA damage repair. It has become increasingly apparent that the misregulation of histone modification, which is caused by the deregulation of factors that mediate the modification installation, removal and/or interpretation, actively contributes to human cancer. In this Review, the authors summarize recent advances in understanding the interpretation of certain histone methylations by plant homeodomain finger-containing proteins, and how misreading, miswriting and mis-erasing of histone methylation marks can be associated with oncogenesis and progression. These observations provide a greater mechanistic understanding of epigenetic alterations in human cancers and might also help direct new therapeutic interventions in the future.
Chi et al (2010 ) Covalent histone modifications — miswritten, misinterpreted and mis-erased in human cancers. Nature Reviews Cancer 10, 457-469

Martin Eastwood

1 Comment

  1. Rasheel

    Reports of altered epigenetic histone modifications in cancer cells have focused on individual gene promoters and so far none of these changes has been related to clinical outcome.Erectile Dysfunction Tablets Now aberrations of ‘global’ histone modification have been observed in prostate tumour patients. These do relate to clinical outcome, and suggest a useful means of prognosis.

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